Does Endurance Training Protect From Lipotoxicity?
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چکیده
منابع مشابه
Does Endurance Training Protect From Lipotoxicity?
Modest regular exercise and reduction of dietary fat halves the risk of developing type 2 diabetes. In overt type 2 diabetes, higher levels of exercise training improve glycemic control, whereas the impact of diet and optimal dietary composition are presently unknown (1). Thus, one can assume that intensive exercise protects from diet-induced insulin resistance. Intravenous lipid infusion is an...
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Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for caveolae by caveolin-1 re-expression. We find that the Cav1-null cells have a modestly enhanced rate...
متن کاملDoes Endurance Training Compensate for Neurotrophin Deficiency Following Diabetic Neuropathy?
BACKGROUND A lack of neurotrophic support is believed to contribute to the development of diabetic neuropathy. On the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in diabetic neuropathy are not u...
متن کاملGlucose ingestion during endurance training does not alter adaptation.
Glucose ingestion during exercise attenuates activation of metabolic enzymes and expression of important transport proteins. In light of this, we hypothesized that glucose ingestion during training would result in 1) an attenuation of the increase in fatty acid uptake and oxidation during exercise, 2) lower citrate synthase (CS) and beta-hydroxyacyl-CoA dehydrogenase (beta-HAD) activity and gly...
متن کاملDoes Endurance Exercise Training Increase the Need for Dietary Antioxidants?
1 KEY POINTS • Prolonged exercise at 65-80% VO 2 max increases the production of radicals in the contracting skeletal muscles. This exercise-induced radical production often results in oxidative damage to skeletal muscle fibers and contributes to muscle fatigue. • Antioxidant supplements are widely available and are commonly consumed by endurance athletes. Arguments exist both for and against t...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2012
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-0662